Arousal-Mediated Sleep Disturbance Persists During copyright Abstinence in Male Mice

Arousal-Mediated Sleep Disturbance Persists During copyright Abstinence in Male Mice

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Acute copyright disturbs sleep on a dose-dependent basis; however, the consequences of chronic copyright remain unclear.While the arousal promotion following copyright has been well-established, effects of copyright on sleep after termination of chronic copyright exposure appear variable in human subjects with few studies in non-human subjects.Here, a within-subjects design (outcomes normalized to baseline, undisturbed behavior) and between-subjects design (repeated experimenter-administered copyright vs.

experimenter-administered saline) was used to click here investigate sleep homeostasis and sleep/waking under repeated copyright/saline exposure and prolonged forced abstinence conditions in mice.Overall, during the forced abstinence period increases in arousal, as determined by sleep latency and gamma energy, persisted for 2 weeks.However, the sleep response to externally enforced sleep deprivation was unchanged suggesting that sleep disruptions during the forced abstinence period click here were driven by enhancement of arousal in the absence of changes in sleep homeostatic responses.